Acyclovir injection 250mg

Other warnings and precautions The labels shall contain the following statements: Any drugs administered concurrently that compete with this mechanism may increase aciclovir plasma concentrations. Probenecid and cimetidine increase the AUC of aciclovir by this mechanism and reduce aciclovir renal clearance. However no dosage adjustment is necessary because of the wide therapeutic index of aciclovir.

In patients receiving intravenous Zovirax caution is required during concurrent administration with drugs which compete with aciclovir for elimination, because of the potential for increased plasma levels of one or both drugs or their metabolites.

Increases in plasma AUCs of aciclovir and of the inactive metabolite of mycophenolate mofetil, an immunosuppressant agent used in transplant patients, have been shown when the drugs are coadministered. If lithium is administered concurrently with high dose aciclovir IV, the lithium serum concentration should be closely monitored because of the risk of lithium toxicity. Care is also required with monitoring for changes in renal function if administering intravenous Zovirax with drugs which affect other aspects of renal physiology e.

It is recommended to measure plasma concentrations during concomitant therapy with aciclovir. There is no information on the effect of aciclovir on human female fertility. In a study of 20 male patients with normal sperm count, oral aciclovir administered at doses of up to 1g per day for up to six months has been shown to have no clinically significant effect on sperm count, motility or morphology.

These exposures resulted in plasma levels the same as, 4 and 9, and 1 and 2 times, respectively, human levels. There are no adequate and well-controlled studies in pregnant women.

A prospective epidemiologic registry of acyclovir use during pregnancy was established in and completed in April There were pregnancies followed in women exposed to systemic acyclovir during the first trimester of pregnancy resulting in outcomes. The occurrence rate of birth defects approximates that found in the general population.

However, the small size of the registry is insufficient to evaluate the risk for less common defects or to permit reliable or definitive conclusions regarding the safety of acyclovir in pregnant women and their developing fetuses. Acyclovir should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.

Nursing Mothers Acyclovir concentrations have been documented in breast milk in 2 women following oral administration of acyclovir and ranged from 0.

These concentrations would potentially expose the nursing infant to a dose of acyclovir up to 0. Herpes infections are contagious and you can infect other people, even while you are being treated with acyclovir. Avoid letting infected areas come into contact with other people. Avoid touching an infected area and then touching your eyes. Wash your hands frequently to prevent passing the infection to others.

Acyclovir will not prevent the spread of genital herpes. Adverse events that have been reported in association with overdosage include agitation, coma , seizures, and lethargy. Precipitation of acyclovir in renal tubules may occur when the solubility 2. Overdosage has been reported following bolus injections or inappropriately high doses, and in patients whose fluid and electrolyte balance were not properly monitored.

This has resulted in elevated BUN and serum creatinine , and subsequent renal failure. Aggressive behavior, agitation, ataxia, coma, confusion, delirium, dizziness, dysarthria, encephalopathy, hallucinations, obtundation, paresthesia, psychosis, seizure, somnolence, tremor. Alopecia, erythema multiforme, photosensitive rash, pruritus, rash, Stevens-Johnson syndrome, toxic epidermal necrolysis, urticaria. Severe local inflammatory reactions, including tissue necrosis, have occurred following infusion of acyclovir into extravascular tissues.

Overdosage Overdoses involving ingestions of up to 20 g have been reported. Adverse events that have been reported in association with overdosage include agitation, coma, seizures, and lethargy. Precipitation of acyclovir in renal tubules may occur when the solubility 2. Overdosage has been reported following bolus injections or inappropriately high doses, and in patients whose fluid and electrolyte balance were not properly monitored.

This has resulted in elevated BUN and serum creatinine, and subsequent renal failure. In trials evaluating continuous administration to prevent recurrences, the most frequently reported adverse reactions included nausea and diarrhea and in those evaluating intermittent treatment of recurrences over one year diarrhea, nausea and headache were reported.

The most frequently reported adverse reaction during clinical trials of shingles was malaise. Lastly, during clinical trials of treatment of chickenpox with acyclovir, the most frequently reported adverse reaction was diarrhea.

More serious side effects of acyclovir are possible with treatment. Kidney failure, in some cases causing death, has been reported with acyclovir treatment. Patients are advised to maintain adequate hydration and drink plenty of water while taking acyclovir to keep the kidneys working properly.

Patients should be advised to contact their health care provider immediately if they experience symptoms which may indicate the occurrence of more serious side effects of acyclovir. Symptoms may include pain the lower back, urinating less than usual or not urinating at all, easy bruising or bleeding, and unusual weakness. Patients are instructed to consult with their health care provider if they experience any other unusual, severe or troublesome side effects while being treated with acyclovir.

Is there an acyclovir ointment? Acyclovir ointment is indicated for the management of initial genital herpes and in limited non-life threatening mucocutaneous herpes simplex virus infections in immunocompromised patients.

Acyclovir ointment is not indicated for the prevention of viral transmission to other individuals. Acyclovir ointment is also not indicated for the prevention of recurrent herpes infections. Acyclovir ointment is a prescription ointment that is applied directly to genital herpes lesions and may lessen the duration of the symptoms associated with an initial outbreak.

For the management of genital herpes, patients should be instructed regarding appropriate dosage and administration of acyclovir ointment. Patients should be advised to apply a sufficient quantity of acyclovir ointment to adequately cover all lesions and apply every 3 hours, 6 times daily, for 7 days of treatment. The dose size of acyclovir ointment for each application may vary depending on the size of the lesion area. Patients should be advised to wear a rubber glove or finger cot when applying acyclovir ointment to the affected area to avoid spreading the virus.

Acyclovir ointment should be applied as early as possible after the development of signs and symptoms. Patients should be advised not to exceed the recommended dosage, frequency of applications and length of treatment. How long is acyclovir treatment? How long acyclovir Zovirax treatment is intended for depends upon the indication for use. Acyclovir is a prescription antiviral agent approved, by the U.

Acyclovir Injection

Reconstitution and dilution should therefore be carried out under full aseptic conditions immediately before use and any unused solution discarded. Patients should be advised to contact their health care provider immediately if they experience symptoms which may indicate the occurrence of more serious side effects of acyclovir. In clinical practice experience with acyclovir, patients reported experiencing diarrhea, gastrointestinal distress and nausea. Patients being treated with acyclovir are advised to stay adequately hydrated and take each dose with a full glass of water to protect the kidneys. Elevated liver function tests, hepatitis, hyperbilirubinemia, jaundice. Caution is therefore advised if Zovirax is to be administered to a nursing woman, acyclovir injection 250mg. Both elderly patients and patients with renal injection are at increased risk of developing neurological side effects and should be closely monitored for evidence of these effects. The other acyclovir is chronic suppressive therapy in which acyclovir treatment is used 250mg up to 12 months and followed by re-evaluation by a health care provider to assess the need for continued treatment. For acyclovir treatment of chickenpox, information gathered during clinical studies reflects initiation of treatment within 24 hours following rash. Because they are reported voluntarily from a population of unknown size, estimates of frequency cannot be made. In obese patients dosed with intravenous aciclovir based on their actual body weight, higher plasma concentrations may be obtained see 5. These concentrations would potentially expose the nursing infant to a dose of acyclovir up to 0. The risk of renal impairment is increased by use with other nephrotoxic drugs. These exposures resulted in plasma levels the same as, acyclovir injection 250mg, 4 and 9, and 1 and 2 times, respectively, human levels. This drug is known to be substantially excreted by the kidneyand the risk of toxic reactions to this injection may be greater in patients with impaired renal function. Neonatal Herpes Simplex 250mg Infection Acyclovir Injection is indicated for the treatment of neonatal herpes infections. You can also report them to the U.


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